Name: Creamy Chicken Alfredo Lasagna Roll-Ups Recipe
Prep time: 15 min
Cook time: 35 min
Total time: 50 min
Cuisine: Italian
Ingredients: 12 uncooked lasagna noodles; 1 teaspoon salt (for boiling noodles); ⅓ cup butter; 3 cloves garlic; 1 tablespoon all-purpose flour; 1 ½ cups milk (2% or whole); 1 cup heavy whipping cream; ¾ cup parmesan cheese; ½ teaspoon salt; ¼ teaspoon ground black pepper; ⅛ teaspoon ground nutmeg (optional); 3 cups cooked shredded chicken; 2 cups shredded mozzarella cheese; 2 tablespoons chopped fresh parsley

Nothing beats the cozy comfort of pasta wrapped around creamy sauce and tender chicken, which is exactly why I adore this Creamy Chicken Alfredo Lasagna Roll-Ups Recipe. It’s like a hug on a plate, and it’s perfect when you want dinner that’s both impressive and satisfying.

A close-up view of a folded lasagna noodle rolled into a tube shape, filled with creamy white cheese sauce that is slightly speckled with black pepper. The lasagna has a golden-brown baked top layer with a light sprinkling of chopped green herbs. The noodles have a wavy edge and gooey melted cheese strands stretch from the bottom of the tube, showing the rich texture of the filling. The lasagna is held by a wooden spatula against a blurred white marbled surface background. photo taken with an iphone --ar 2:3 --v 7

Jump to:

Why You'll Love This Recipe
Ingredients & Why They Work
Make It Your Way
Step-by-Step: How I Make Creamy Chicken Alfredo Lasagna Roll-Ups Recipe
Top Tip
How to Serve Creamy Chicken Alfredo Lasagna Roll-Ups Recipe
Make Ahead and Storage
Frequently Asked Questions:
Final Thoughts
Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Why You'll Love This Recipe

This recipe quickly became a favorite in my household because it combines that classic creamy Alfredo flavor with the fun and approachable format of lasagna roll-ups. Everyone gets their own cheesy, saucy bundle, so it’s a real crowd-pleaser for family dinners or small get-togethers.

Individual Portions: Each roll-up holds its own perfect serving, making it easy to serve and avoid leftovers piling up.
Creamy, Comforting Flavors: The homemade Alfredo sauce is rich but balanced, with just the right touch of garlic and Parmesan.
Simple Prep: You don’t need to fuss with layering a whole lasagna—rolling things up is fast and actually kind of fun.
Customizable: You can easily add veggies, swap proteins, or tweak the cheese to make it your own.

A white rectangular baking dish holds a creamy, golden-brown baked lasagna with about three visible layers. The top layer is slightly browned melted cheese with small green herb sprinkles, giving it a soft, bubbly texture. Beneath, cream-colored pasta sheets are layered evenly, with hints of white sauce and light yellow fillings showing from the sides. The edges of the dish show a creamy sauce that has thickened during baking. The background is a white marbled surface. Photo taken with an iphone --ar 2:3 --v 7

Ingredients & Why They Work

Let’s chat about the stars of this meal. The ingredients blend perfectly to create that velvety, cheesy sauce that coats the shredded chicken and pasta. Plus, the fresh parsley on top adds a lovely pop of color and brightness that cuts through the richness.

Flat lay of uncooked lasagna noodles neatly stacked, a few whole brown garlic bulbs with papery skins, a stick of golden butter, a small white bowl of all-purpose flour, a small white bowl filled with creamy milk, a small white bowl with heavy whipping cream, a chunk of pale parmesan cheese, a small white bowl holding ground black pepper, a small white bowl with ground nutmeg powder, a mound of cooked shredded white chicken breast, a pile of shredded mozzarella cheese, and a few sprigs of fresh green parsley, all arranged in perfect symmetry on simple white ceramic plates and bowls, placed on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997

Uncooked Lasagna Noodles: These are the foundation. Cooking them al dente keeps your roll-ups from getting mushy when baked.
Butter: Starting the Alfredo sauce with butter gives a silky richness that you can almost taste in every bite.
Garlic: Fresh cloves infuse the sauce with classic aroma and depth—it’s worth mincing them yourself.
All-Purpose Flour: This helps thicken the sauce to that perfect creamy consistency without lumps.
Milk & Heavy Whipping Cream: Using both creates the ideal balance of creaminess without making it too heavy or too light.
Parmesan Cheese: Freshly grated Parmesan adds savory, nutty flavor and helps thicken the sauce as it melts.
Cooked Shredded Chicken: A great way to use leftover chicken or rotisserie chicken—adds protein and heartiness.
Mozzarella Cheese: Melts beautifully on top and inside, giving you that irresistible cheesy pull.
Salt, Black Pepper, Nutmeg: Salt and pepper are the essentials for seasoning; the tiny hint of nutmeg elevates the Alfredo sauce with a subtle warmth.
Fresh Parsley: Sprinkle on top right before serving to brighten up the dish and add a fresh contrast.

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Note: You'll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Make It Your Way

I love switching up this dish depending on the mood or what I have on hand. It’s super flexible, so feel free to make it your own!

Variation: Sometimes I swap the chicken for sautéed mushrooms or spinach to make it vegetarian—still delicious and creamy.
Dietary Modifications: You can use gluten-free lasagna noodles and substitute milk with almond or oat milk for a lactose free version.
Spicy Kick: Adding a pinch of crushed red pepper flakes into the sauce brings a nice heat that pairs wonderfully with the creamy base.

Step-by-Step: How I Make Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Step 1: Perfectly Cook the Noodles

Start by cooking your lasagna noodles in salted boiling water until just al dente—this means they should still have a bite. Overcooking makes them too soft to roll later. Drain and immediately place them in a pot with room temperature water to prevent sticking. This little trick saved me so many times from frustrating noodle clumps!

Step 2: Make the Creamy Alfredo Sauce

In a pan over medium heat, melt the butter and sauté minced garlic until fragrant—about 1 minute. Stir in the flour to form a roux and cook it for another minute to remove that raw flour taste. Slowly whisk in the milk and heavy cream, letting it simmer gently for 2 minutes. Then, add your parmesan, salt, pepper, and just a hint of nutmeg (if you’re using it). Keep whisking until the sauce thickens and cheese melts into a luscious, creamy texture. If it gets too thick, adding a splash of milk is an easy fix.

Step 3: Combine Chicken and Cheese with Sauce

Take a cup of the Alfredo sauce and mix it with your cooked shredded chicken and a cup of mozzarella cheese in a bowl. Season lightly with salt and pepper. This mixture is what you’ll spread onto each noodle, so it’s key for that rich, cheesy filling.

Step 4: Roll and Arrange

On a clean surface, lay out each noodle and spoon an even layer of your chicken and cheese filling along one edge. Roll it up gently but firmly. Place each roll seam-side down in a greased 9x13 pan, then spoon the remaining Alfredo sauce evenly over the top. Sprinkle the remaining mozzarella for a beautifully golden finish.

Step 5: Bake and Enjoy

Bake in your preheated oven at 375°F (190°C) for about 30-35 minutes or until the tops are bubbly and golden. A few minutes under the broiler at the end can make the cheese extra crispy if you’re feeling indulgent. Let them rest for a few minutes before digging in to help everything set perfectly.

Top Tip

After making this recipe a handful of times, I’ve learned a few tricks that really make a difference in how well your roll-ups come together and taste.

Don’t Overcook the Noodles: Leaving them slightly firm gives you noodles that roll without tearing or turning mushy.
Season the Sauce Well: Since this sauce is the star, don’t be shy with salt and pepper—it really brings out the flavors.
Sauce on the Bottom: Spreading some sauce on the baking dish before adding the roll-ups keeps them moist and prevents sticking.
Let it Cool a Bit: Giving the rolls a few minutes after baking helps them hold their shape instead of unraveling when you serve.

How to Serve Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Chicken Alfredo Lasagna - Serving Suggestion

Garnishes

I usually finish mine with a sprinkle of freshly chopped parsley—it makes the dish look so fresh and inviting. Sometimes, I add a bit of extra grated Parmesan at the end if we’re feeling extra cheesy. A grind of fresh black pepper on top never hurts either.

Side Dishes

To balance out the richness, I like serving this with a simple green salad with lemon vinaigrette or some roasted seasonal vegetables—think asparagus or broccoli. Garlic bread or crusty Italian bread also pairs perfectly if you want to keep that comforting Italian vibe going.

Creative Ways to Present

For special occasions, I’ve arranged the roll-ups standing vertically in the dish like mini towers, then topped each with a basil leaf for a fancy touch. You can also make individual servings by baking roll-ups in ramekins—makes for a charming presentation at dinner parties.

Make Ahead and Storage

Storing Leftovers

I store leftovers in an airtight container in the fridge. The roll-ups actually taste great the next day after giving them a quick zap in the microwave, though the texture of the noodles softens a little. I usually add a splash of milk over the top before reheating to keep them moist.

Freezing

When I want to prep ahead, I assemble the roll-ups, cover the baking dish tightly with foil, and freeze. When ready to eat, I bake them straight from the freezer—just add about 15 minutes extra cooking time. It’s great for a stress-free dinner later in the week!

Reheating

I find reheating in the oven at 350°F (175°C) covered with foil keeps the roll-ups moist and prevents the cheese from getting rubbery. About 20 minutes usually does the trick. If you’re short on time, a microwave covered with a damp paper towel works too, just watch for dryness.

Frequently Asked Questions:

Can I use pre-cooked chicken from the store?

Absolutely! Using rotisserie or pre-cooked shredded chicken is a great shortcut that adds flavor and convenience without sacrificing the creaminess of the dish.

Can I freeze these roll-ups before baking?

Yes, you can assemble the roll-ups in a baking dish, cover tightly with foil, and freeze. Bake from frozen, adding extra baking time to ensure they are heated through.

What can I serve alongside Creamy Chicken Alfredo Lasagna Roll-Ups Recipe?

Simple sides like green salad, roasted vegetables, or garlic bread complement the rich flavors perfectly and bring balance to the meal.

How do I prevent the lasagna noodles from sticking?

After cooking, immediately placing the noodles in room temperature water keeps them from sticking together and makes rolling much easier. Also, a bit of oil in the water can help.

Final Thoughts

This Creamy Chicken Alfredo Lasagna Roll-Ups Recipe is one of those gems I’m always happy to share because it brings the flavors of a classic favorite, but in a simpler, fresher form. It’s got that perfect cheesy creaminess I crave, with the convenience of easy portions. I really think you’ll enjoy making it as much as eating it—give it a try next time you want something cozy and special!