Name: Blackened Chicken Alfredo Lasagna Roll Ups Recipe
Prep time: 30 min
Cook time: 35 min
Total time: 1 h 5 min
Cuisine: American
Ingredients: 12 lasagna noodle sheets; 3 chicken breasts (thighs, cutlets or tenders work too); 4 tablespoons olive oil; 2 tablespoons Cajun seasoning (see seasoning recipe below); 2 tablespoons smoked paprika (regular paprika works too); 1 tablespoon cayenne pepper; 1 tablespoon onion powder; 2 teaspoons brown sugar; 2 teaspoons garlic powder; 1 teaspoon ground black pepper; 1 teaspoon salt; 1/2 teaspoon dried thyme; 1/2 teaspoon dried oregano; 6 tablespoons butter; 6-8 large cloves garlic, minced; 2 cups heavy whipping cream; 1-2 teaspoons Cajun seasoning; 1 cup grated Parmesan cheese; Salt and pepper to taste; 1/2 block cream cheese, softened; 1 15 oz container ricotta cheese; 12 oz frozen chopped spinach, drained well; 2-3 teaspoons Cajun seasoning; Prepared chicken, diced; 1 8 oz block mozzarella cheese, shredded (divided); 1 8 oz block Colby Jack cheese, shredded (divided); Garlic bread or Texas toast

Imagine tender chicken kissed with bold spices, wrapped up in cheesy, creamy goodness—that’s exactly what makes the Blackened Chicken Alfredo Lasagna Roll Ups Recipe unforgettable. It’s a comfort food celebration with a little spicy kick that always impresses at dinner.

A white ceramic baking dish holds a rich, three-layered cheesy casserole. The top layer is golden-brown melted cheese with bubbly browned spots and small green herb pieces sprinkled all over. Below the cheese, there is a creamy white sauce that looks thick and smooth. A woman's hand is lifting a large portion with melted cheese strings stretching from the dish, revealing layers of tender pasta and creamy layers beneath. The dish sits on a white marbled surface, highlighting the warm colors of the casserole. photo taken with an iphone --ar 2:3 --v 7

Jump to:

Why You'll Love This Recipe
Ingredients & Why They Work
Make It Your Way
Step-by-Step: How I Make Blackened Chicken Alfredo Lasagna Roll Ups Recipe
Top Tip
How to Serve Blackened Chicken Alfredo Lasagna Roll Ups Recipe
Make Ahead and Storage
Frequently Asked Questions:
Final Thoughts
Blackened Chicken Alfredo Lasagna Roll Ups Recipe

Why You'll Love This Recipe

Every time I make this Blackened Chicken Alfredo Lasagna Roll Ups Recipe, my kitchen fills with sizzling spices and creamy richness that’s downright irresistible. Here’s why you’ll want to add it to your meal rotation ASAP.

Flavor-packed layers: The blackened chicken provides a smoky, spicy punch that pairs perfectly with the velvety Alfredo sauce.
Make-ahead friendly: You can prep these roll ups in advance and pop them in the oven when ready—ideal for busy weeknights or entertaining.
Comfort food elevated: It’s classic lasagna, but rolled, which means every bite is packed with cheesy, garlicky goodness and a refreshing touch of spinach.
Customizable spice level: Easily adjust the Cajun seasoning to make it as mild or bold as you like.

This dish shows a thick slice of creamy, cheesy casserole lifted on a fork above a white baking dish. The casserole has three visible layers: the top is a golden-brown, bubbly melted cheese with small green herbs sprinkled on it; beneath is a thick, white creamy sauce speckled with herbs and spices; the base layer looks like soft pasta sheets covered in sauce. The casserole is gooey with melted cheese stretching slightly from the fork. The white baking dish has a ridged edge and the background is a white marbled texture. Photo taken with an iphone --ar 2:3 --v 7

Ingredients & Why They Work

This recipe brings together creamy cheeses, tender chicken, and fresh garlic in a way that feels decadent yet approachable. Each ingredient adds a layer of flavor or texture that makes these roll ups sing.

Flat lay of fresh uncooked lasagna noodle sheets stacked neatly, three raw whole chicken breasts with smooth skin, a small white bowl of bright golden olive oil, a small white bowl of vibrant red smoked paprika powder, a small white bowl of deep red cayenne pepper, a small white bowl of light beige onion powder, a small white bowl of brown sugar crystals, a small white bowl of fine garlic powder, a small white bowl of cracked black pepper, a small white bowl of coarse salt, a small white bowl of dried thyme leaves, a small white bowl of dried oregano leaves, a small white bowl of creamy softened cream cheese block, a small white bowl of white ricotta cheese with a slightly grainy texture, a small white bowl of finely grated pale parmesan cheese, a small white bowl of yellow shredded colby jack cheese, a small white bowl of white shredded mozzarella cheese, a small white bowl of minced fresh garlic cloves, a small white bowl of fresh bright green chopped spinach (drained), all ingredients arranged symmetrically and balanced, placed on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997

Lasagna noodle sheets: Using wide, sturdy noodles makes rolling up the filling easy without tearing.
Chicken breasts: I like using boneless skinless for tender, easy-to-cut pieces, but thighs add juiciness if you prefer.
Olive oil: Perfect for searing the chicken and building flavor in the seasoning.
Cajun seasoning: The star spice blend giving the chicken that irresistible blackened crust and the sauce its signature kick.
Butter and garlic: Infuse the Alfredo sauce with rich, aromatic notes that make all the difference.
Heavy whipping cream: Creates the silky, luscious texture that transforms this sauce into a dream.
Parmesan cheese: Adds salty, nutty depth and helps thicken the sauce.
Cream cheese and ricotta: Together, they make the filling extra creamy and keep the roll ups moist.
Frozen chopped spinach: Drained well, it adds color, nutrients, and a fresh dimension that balances the richness.
Mozzarella and Colby Jack cheese: These melt beautifully on top, creating a golden, bubbly crust.
Smoked paprika, cayenne, onion powder, brown sugar, garlic powder, black pepper, salt, thyme, oregano: Combining these spices creates the homemade Cajun seasoning with a perfect balance of smoky, sweet, and spicy.

📝

Note: You'll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Make It Your Way

I love tweaking this Blackened Chicken Alfredo Lasagna Roll Ups Recipe depending on what we have in the fridge or my mood – it’s very forgiving and flexible!

Variation: One time, I swapped chicken for shrimp, blackening them the same way, and it was amazing with a hint of coastal flair.
Diet Adaptation: Use gluten-free lasagna sheets if you’re avoiding gluten, and the roll ups come out just as delicious.
Heat Level: If you want to dial down the spice, simply reduce the cayenne and paprika, or swap in mild paprika.
Veggie Boost: You can add sautéed mushrooms or roasted red peppers in the filling – they add such great texture and flavor.

Step-by-Step: How I Make Blackened Chicken Alfredo Lasagna Roll Ups Recipe

Step 1: Prep and Blacken the Chicken

Start by mixing your Cajun seasoning with smoked paprika, cayenne, garlic powder, and the rest of the spices—making your own blend is a game changer. Pat dry the chicken breasts, brush them lightly with olive oil, then evenly coat with the seasoning mix. Sear in a hot pan with olive oil for about 5-6 minutes per side until a dark crust forms and the chicken is cooked through. Let it rest so the juices redistribute, then dice it into bite-size pieces. This step is key to getting that authentic smoky, spicy flavor that sets these roll ups apart.

Step 2: Make the Creamy Alfredo Sauce

Sauté the minced garlic gently in butter until fragrant but not brown—this releases the sweet garlic aroma without bitterness. Pour in heavy cream and add a teaspoon or two of Cajun seasoning for consistency in flavor. Slowly whisk in parmesan cheese and soften cream cheese until the sauce is smooth, rich, and velvety. Adjust salt and pepper as you go—you want that perfect savory balance to complement the spicy chicken.

Step 3: Prepare the Filling

In a bowl, blend ricotta, softened cream cheese, drained chopped spinach, diced blackened chicken, and a bit of the Cajun seasoning. This combo packs moisture, creaminess, and a hit of spice right into each roll. It’s like a flavor party in every bite. Don’t skip draining the spinach well — too much moisture can make the roll ups soggy.

Step 4: Assemble the Roll Ups

Cook lasagna noodles according to package instructions until al dente—firm but flexible. Lay each noodle flat on a clean surface, spread a generous layer of your filling evenly, then gently roll it up from one end to the other. Arrange them seam side down in your greased baking dish, which keeps them intact while baking.

Step 5: Bake to Perfection

Pour the Alfredo sauce evenly over the roll ups, then top with shredded mozzarella and Colby Jack cheeses. Bake at 375°F for about 35 minutes until the cheese is bubbly and golden brown. Let them rest for a few minutes before serving – it helps everything set so your roll ups slice neatly and don’t fall apart.

Top Tip

From my many attempts with this recipe, a few key tips really make the difference between a good and a great dinner.

Patience on the chicken: Let your seasoned chicken rest after cooking—it keeps it juicy and lets the spices settle before dicing.
Drain spinach thoroughly: Excess water from spinach can turn your filling watery and make rolling messy.
Don’t overcook noodles: Lasagna sheets should be pliable but still a bit firm since they’ll cook more in the oven.
Generous cheese topping: The melty cheese crust on top adds that irresistible golden finish and extra flavor punch.

How to Serve Blackened Chicken Alfredo Lasagna Roll Ups Recipe

Blackened Chicken Alfredo - Serving Suggestion

Garnishes

I like to sprinkle chopped fresh parsley or basil over the finished roll ups for a pop of color and freshness. A little cracked black pepper on top never hurts, and a drizzle of extra creamy Alfredo sauce always takes it over the top.

Side Dishes

This dish pairs beautifully with a crisp green salad or roasted veggies to lighten things up. For a cozy meal, I often throw some garlic bread or Texas toast in the oven to soak up every last bit of sauce.

Creative Ways to Present

For a dinner party, I love serving each rolled lasagna on individual plates with a drizzle of sauce artistically swirled around and a sprig of fresh herbs on top. It feels elegant but stays deliciously casual.

Make Ahead and Storage

Storing Leftovers

I always store leftover roll ups covered tightly in an airtight container in the fridge for up to 3 days. They reheat beautifully and even taste better as the flavors meld overnight.

Freezing

This recipe freezes really well—just assemble the roll ups, don’t bake, and freeze them individually on a tray before transferring to a bag. When you’re ready, thaw overnight and bake as usual.

Reheating

Reheat leftovers covered in the oven at 350°F until warmed through, about 20 minutes. Covering them helps keep the cheese moist and melty instead of drying out.

Frequently Asked Questions:

Can I use pre-cooked chicken for this recipe?

Absolutely! Using pre-cooked chicken can save time. Just make sure it’s seasoned well to keep the bold blackened flavor. You might want to toss it briefly in the pan with a bit of Cajun seasoning to refresh the spices before mixing into the filling.

What can I substitute for heavy cream in the Alfredo sauce?

You can substitute heavy cream with half and half mixed with a bit of butter for richness, or use whole milk combined with cream cheese for a thick, creamy texture. Just note that the sauce may be slightly lighter and less rich.

How do I prevent the lasagna roll ups from falling apart?

The key is to not overfill the noodles and roll them up gently but firmly. Placing the rolls seam-side down in the baking dish helps them hold during cooking. Also, letting them rest after baking gives the filling time to set, preventing them from unrolling when sliced.

Can I make the Cajun seasoning blend ahead of time?

Definitely! Making a batch of Cajun seasoning ahead is a great idea—it keeps well stored in an airtight container for weeks, so you’ll always have it ready to spice up your dishes, including this recipe.

Final Thoughts

The Blackened Chicken Alfredo Lasagna Roll Ups Recipe has become one of my go-to dishes when I want something that’s comforting but not boring. The combination of spicy blackened chicken and indulgent creamy sauce wrapped in cheesy noodles just hits all the right notes. I hope you try this recipe and enjoy it as much as I do—because good food shared with friends always tastes better.